Molecular Formula | C21H30O4 |
Molar Mass | 346.46 |
Density | 1.131±0.06 g/cm3(Predicted) |
Boling Point | 505.1±50.0 °C(Predicted) |
Appearance | Powder |
pKa | 4.12±0.40(Predicted) |
Storage Condition | -20°C |
In vitro study | 12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7%. 12-O-Methylcarnosic acid shows antimicrobial activity against S. aureus at 78 μg/mL. |
Risk Codes | R22 - Harmful if swallowed R50 - Very Toxic to aquatic organisms |
Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
UN IDs | UN 3077 9 / PGIII |
WGK Germany | 3 |
Biological activity | 12-O-Methylcarnosic acid (12-Methoxycarnosic acid) is a diterpene cinnamic acid isolated from the acetone extract of Salvia miltiorrhiza. It is an active ingredient inhibited by 5 α-reductase (5α-reductase), and its IC50 is 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation of LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anticancer and antimicrobial activities. |
in vitro study | 12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7%. 12-O-Methylcarnosic acid shows antimicrobial activity against S. aureus at 78 μg/mL. |